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The Science

Antiseptic

Antiseptic Lotion

Foaming Hand Soap

Surgical Scrub

Antiseptic Wipes

Clinical Data

The Science

Antiseptic

  1. Rapid bacterial kill1

    2. For any anticeptic product, it is essential that it kills germs on contact.  Within 15 seconds, the Zylast™ Sanitizer killed more than 99.99% of:

    • Staphylococcus epidermis
    • Staphylococcus aureus
    • MRSA (Methicillin-resistant Staphylococcus aureus)
    • VRE (Vancomycin-resistant Enterococcus faecium
    • Enterobacter aerogenes
    • Serratia marcescens
    • E. coli
    • Klebsiella pneumonia
    • Pseudomonas aeruginosa
    • Acinetobacter baumanni

  2. Rapid viral kill

    3. Many alcohol-based sanitizers kill bacteria on contact, but are ineffective against viruses.  The Zylast™ sanitizer was tested and shown to be effective against common and dangerous viruses that cause disease.

     

    15 Seconds

    30 Seconds

    H1N16

    4 log reduction

    ---

    Rhinovirus1

    2.5 log reduction

    2.8 log reduction

    Rotavirus1

    3.0 log reduction

    3.5 log reduction

  3. FDA-required in vivo testing1

    4. Rapid Viral Kill

    In testing according to the FDA protocol, the Zylast™ hand sanitizer was demonstrated to kill more than 10 times the minimum FDA requirement after the first application, and more than 100 times the requirement after the tenth application.  The testing was performed against S. marcescens.


  4. Testing against MRSA, VRE, and S. aureus2

    5. Hospital-acquired infections are becoming more dangerous as antibiotic resistant bacteria evolve and spread.  The Zylast™ Antiseptic was tested against two of the most dangerous, Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant enterococci (VRE) for immediate kill, as well as persistent kill, with S. Aureus serving as a comparison.

     

    2 minutes

    1 hour

    4 hours

    vs. MRSA*

    100%

    97%

    62%

    vs. VRE*

    100%

    91%

    70%

    vs. Staph*

    ---

    99.4%

    98%

    Using an in-vitro skin model, the persistence of the Zylast™ hand sanitizer was tested against the three strains.  The sanitizer was applied to the skin model, and the organism introduced after the specified amount of time. 

  5. Norivirus Testing

    6. The Norovirus is one of the leading causes of outbreaks of gastrointestinal distress.  It is virulent and particularly dangerous in areas where large numbers of people are living in close quarters – nursing homes, hospitals, military bases, cruise lines. 

    More importantly, a standard alchol-based product like Purell has almost no effect on the Norovirus.  In fact, studies have shown that it is more effective to rinse your hands with water than use an alcohol sanitizer against the Norovirus!

    In clinical testing against the approved Norovirus substitute, the Zylast™ Antiseptic was demonstrated to kill 99.97% of the virus.

    Sanitizer exceeds FDA Requirements

  6. Comparison against other leading products1

    7. Testing agains MRSA, VRE, Staph

    Norovirus Kill

    To compare the Zylast™ hand sanitizer against other products on the market that make claims of persistence, it was evaluated against Avagard™, Prevacare™, Triseptin®, and against a standard alcohol base.  Two types of bacteria (e. coli and S. aureus) were chosen to compare the effect on gram negative and gram positive types.  A total of 0.3 ml of each product was spread onto the model, and then challenged with the bacteria at 20 minutes and at 35 minutes.  The graph summarizes the results.

    As can be seen in the above charts, Zylast™ significantly outperforms all other competitors.  Both Triseptin™(S. aureus) and Prevacare™(e. coli, 20 min) perform worse than the alcohol gel, which has no persistence at all. 

    The Zylast™ hand sanitizer is more than 10 times more effective than any competitor in reducing gram positive or gram negative bacteria at 20 and 35 minutes after application.

  7. Skin Irritation Study1

    8. In a study to determine skin irritation, the Zylast™ sanitizer was applied to a subject 10 times each day for five consecutive days.  A total of 12 volunteers were used.  No skin irritation was seen in the study.



References


  1. Haskins Laboratory, Pace University, August 21, 2009
  2. Loricon Testing Service, Test #041707SMPSP
  3. AMA Laboratories, Inc., 48 Hour Patch Test Skin Irritation Evaluation (Open Patch), August 10, 2009
  4. Shintre M, Gaonkar T, Modak S, Evaluation of an Alcohol-Based Surgical Hand Disinfectant Containing a Synergistic Combination of Farnesol and Benzethonium Chloride for Immediate and Persistent Activity Against Resident Hand Flora of Volunteers and With a Novel In Vitro Pig Skin Model, Infection Control and Hospital Epidemiology, 28(2), 2007
  5. BioScience Laboratories, Inc., Determination of the Persistent Antimicrobial Efficacy of Three Test Products Using an In-Vitro Skin Substitute, October 6, 2009